Ruth Palmer Lab 
  • Sahlgrenska Academy, Gothenburg University
  • Medicinaregatan 9B, Gothenburg, SE-41390, Sweden



Targeting Anaplastic Lymphoma Kinase in neuroblastoma (2018). APMIS.

Umapathy G, Mendoza-Garcia P, Hallberg B, Palmer RH.

Characterization of Drosophila Nidogen/entactin reveals roles in basement membrane stability, barrier function and nervous system patterning (2018). Development.

Wolfstetter G, Dahlitz I, Pfeifer K, Töpfer U, Alt JA, Pfeifer DC, Lakes-Harlan R, Baumgartner S, Palmer RH, Holz A.


Phosphoproteome  and gene expression profiling of ALK inhibition in neuroblastoma cell  lines reveals conserved oncogenic pathways (2018). Science Signaling.

Van den Eynden J, Umapathy G, Ashouri A, Cervantes-Madrid D, Szydzik J, Ruuth K, Koster J, Larsson E, Guan J, Palmer RH, Hallberg B.

Drosophila model of myosin myopathy rescued by overexpression of a TRIM-protein family member (2018). PNAS.

Dahl-Halvarsson M, Olive M, Pokrzywa M, Ejeskär K, Palmer RH, Uv AE, Tajsharghi H.

Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib (2018). Cold Spring Harb Mol Case Stud.

Guan J, Fransson S, Siaw JT, Treis D, Van den Eynden J, Chand D,  Umapathy G, Ruuth K, Svenberg P, Wessman S, Shamikh A, Jacobsson H,  Gordon L, Stenman J, Svensson PJ, Hansson M, Larsson E, Martinsson T, Palmer RH, Kogner P, Hallberg B.

ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells (2018). PNAS. 

Fadeev A, Mendoza-Garcia P, Irion U, Guan J, Pfeifer K, Wiessner S, Serluca F, Pratap Singha A, Nüsslein-Volhard C and Palmer RH.


MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas (2017). Science Signaling.

Umapathy G, Guan J, Gustafsson DE, Javanmardi N, Cervantes-Madrid D, Djos A, Martinsson T, Palmer RH, Hallberg B.

Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation (2017). Cancers (Basel).

Guan J, Yamazaki Y, Chand D, van Dijk JR, Ruuth K, Palmer RH, Hallberg B.

The scaffolding protein Cnk Interacts with Alk to Promote Visceral Founder Cell Specification in Drosophila (2017). Science Signaling.

Wolfstetter G, Pfeifer K, vanDijk JR, Hugosson F, Lu X, Palmer RH.

The Zic family homologue Odd-paired regulates Alk expression in Drosophila (2017). PLoS Genetics.

Mendoza-García P, Hugosson F, Fallah M, Higgins ML, Iwasaki Y, Pfeifer K, Wolfstetter G, Varshney G, Popichenko D, Gergen JP, Hens K, Deplancke B, Palmer R.

Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent (2017). Oncotarget.

Guan J, Wolfstetter G, Siaw J, Chand D, Hugosson F, Palmer RH, Hallberg B.


The role of the ALK receptor in cancer biology (2016). Annals of oncology.

Hallberg B, Palmer R. 

The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN (2016). Disease Model Mechanisms.

Guan J, Tucker ER, Wan H, Chand D, Danielson LS, Ruuth K, El Wakil A, Witek B, Jamin Y, Umapathy G, Robinson SP, Johnson TW, Smeal T, Martinsson T, Chesler L, Palmer RH, Hallberg B.

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice (2016). Oncotarget.

Siaw JT, Wan H, Pfeifer K, Rivera VM, Guan J, Palmer RH, Hallberg B.

Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs (2016). Nature Cell Biology.

Yamazaki Y, Palmer L, Alexandre C, Kakugawa S, Beckett K, Gaugue I, Palmer RH, Vincent JP.


FAM150A and FAM150B are activating ligands for Anaplastic Lymphoma Kinase (2015). Elife.

Guan J, Umapathy G, Yamazaki Y, Wolfstetter G, Mendoza P, Pfeifer K, Mohammed A, Hugosson F, Zhang H, Hsu AW, Halenbeck R, Hallberg B, Palmer RH.

Targeted disruption of ALK reveals a potential role in hypogonadotropic hypogonadism (2015). PLoS One.

Witek B, El Wakil A, Nord C, Ahlgren U, Eriksson M, Vernersson-Lindahl E, Helland Å, Alexeyev OA, Hallberg B, Palmer RH.

Intragenic Anaplastic Lymphoma Kinase (ALK) rearrangements: translocations as a novel mechanism of ALK activation in neuroblastoma tumors (2015). Genes Chromosomes Cancer.

Fransson S, Hansson M, Ruuth K, Djos A, Berbegall A, Javanmardi N, Abrahamsson J, Palmer RH, Noguera R, Hallberg B, Kogner P, Martinsson T.


The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation (2014). PLoS One.

Hugosson F, Sjören C, Birve A, Hedlund L, Eriksson T, Palmer RH.

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma (2014). Science Signalling.

Umapathy G, El Wakil A, Witek B, Chesler L, Danielson L, Deng X, Gray NS, Johansson M, Kvarnbrink S, Ruuth K, Schönherr C, Palmer RH, Hallberg B.

Tumour-associated mutations of the PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization (2014). Biochemistry Journal.

van Dijk JR, Yamazaki Y, Palmer RH.

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells (2014). PLoS Genetics.

Macagno JP, Diaz-Vera J, Yu Y, MacPherson I, Sandilands E, Palmer RH, Norman JC, Frame M, Vidal M.


Cell and Drosophila model systems define three clases of anaplastic lymphoma kinase mutations in neuroblastoma (2013). Disease Models & Mechanisms.

Chand D, Yamazaki Y, Ruuth K, Schönherr C, Martinsson T, Kogner P, Attiyeh EF, Maris J, Morozova O, Marra MA, Ohira M, Nakagawara A, Sandström PE, Palmer RH, Hallberg B.

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology (2013). Nature Reviews, Cancer.

Hallberg B, Palmer RH. 

Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as functional target of activated ALK in neuroblastoma cells (2013). The FEBS Journal.

Sattu K, Hochgräfe F, Wu J, Umapathy G, Schönherr C, Ruuth K, Chand D, Witek B, Fuchs J, Li PK, Hugosson F, Daly RJ, Palmer RH, Hallberg B.

Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm (2013). Development.

Popichenko D, Hugosson F, Sjögren C, Dogru M, Yamazaki Y, Wolfstetter G, Schönherr C, Fallah M, Hallberg B, Palmer RH.

Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation (2013). EMBO Journal.

Yamazaki Y, Schönherr C, Varshney GK, Dogru M, Hallberg B, Palmer RH.


Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment (2012). PLoS One.

Mazot P, Cazes A, Dingli F, Degoutin J, Irinopoulou T, Boutterin MC, Lombard B, Loew D, Hallberg B, Palmer RH, Delattre O, Janoueix-Lerosey I, Vigny M.

Anaplastic lymphoma kinase in human cancer (2012). Critical Reviews in Oncogenesis.

Schönherr C, Hallberg B, Palmer RH.

Anaplastic lymphoma kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells (2012). Oncogene.

Schönherr C, Ruuth K, Kamaraj S, Wang CL, Yang HL, Combaret V, Djos A, Martinsson T, Christensen JG, Palmer RH, Hallberg B.


Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684 (2011) 

Schönherr C, Ruuth K, Yamazaki Y, Eriksson T, Christensen J, Palmer RH, Hallberg B.

Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumour progression and unresponsiveness to therapy (2011)

 Martinsson T, Eriksson T, Abrahamsson J, Caren H, Hansson M, Kogner P, Kamaraj S, Schönherr C, Weinmar J, Ruuth K, Palmer RH, Hallberg B.

The constitutive active activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking (2011)

Mazot P, Cazes A, Boutterin MC, Figueiredo A, Raynal V, Combaret V, Hallberg B, Palmer RH, Delattre O, Janoueix-Lerosey I, Vigny M.

ALK and NSCLC: targeted therapy with ALK inhibitors (2011)

Hallberg B, Palmer RH.

The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning (2011)

Gouzi JY, Moressis A, Walker JA, Apostolopoulou AA, Palmer RH, Bernards A, Skoulakis EM


Characterization of the role of Vrp1 in cell fusion during the development of visceral muscle of Drosophila melanogaster (2010)

Eriksson T, Varshney G, Aspenström P, Palmer RH.

Midkine and Pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of Heparin-binding growth factors during evolution (2010)

Svensson SL, Pasupuleti M, Walse B, Malmsten M, Mörgelin M, Sjögren C, Olin AI, Collin M, Schmidtchen A, Palmer RH, Egesten A.

Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells (2010)

Schönherr C, Yang HL, Vigny M, Palmer RH, Hallberg B.

Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster (2010)

Haglund K, Nezis IP, Lemus D, Grabbe C, Wesche J, Liestol K, Dikic I, Palmer RH, Stenmark H.

The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster (2010)

Shirinian M, Popvic M, Grabbe C, Varshney G, Hugosson F, Bos H, Rehmann H, Palmer RH.

Crizotinib: latest champion in the cancer wars? (2010)

Hallberg B, Palmer RH.


Anaplastic lymphoma kinase: signalling in development and disease (2009)

Palmer RH, Vernersson E, Grabbe C; et al.

Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm (2009)

Wolfstetter G, Shirinian M, Stute C; et al.

WASP and SCAR have distinct roles in activating the Arp2/3complex during myoblast fusion (2008)

Berger S, Schäfer G, Kesper D; et al.

Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila (2007)

Bazigou E, Apitz H, Johansson J; et al.

The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK (2007)

Yang H, Eriksson T, Vernersson E; et al.

Drosophila Anaplastic Lymphoma Kinase regulates Dpp signalling in the developing embryonic gut (2007)

Shirinian M, Varshney GK, Lorén C; et al.

The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut (2006)

Varshney GK, Palmer RH.

Miple1 and Miple2 encode a family of MK/PTN homologues in Drosophila melanogaster (2006)

Englund C, Birve A, Falileeva L; et al.

Characterization of the expression of the ALK receptor tyrosine kinase in mice (2006)

Vernersson E, Khoo NK, Henriksson ML; et al. 

A directed screen for genes involved in Drosophila blood cell activation (2004)

Zettervall, CA, Ines Williams M; et al.


Focal adhesion kinase is not required for integrin function or viability in Drosophila (2004)

Grabbe C, Zervas CG, Hunter T; et al.

Activation of the MAP kinase pathway by c-Kit­­­­­ ­is ­PI-3 kinase dependent in hematopoietic progenitor/stem cell lines (2004)

Wandzioch E, Edling CE, Palmer RH; et al.

A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster (2003)

Lorén C, Englund C, Grabbe C; et al.

Exoenzyme S shows selective ADP-ribosylation and GTPase-activating protein (GAP) activities towards small GTPases in vivo (2002)

Henriksson ML, Sundin C, Jansson AL; et al.

Ruth Palmer Lab 

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